Risk-reducing salpingo-oophorectomy (RRSO) is usually recommended to BRCA1 or BRCA2 carriers after completion of childbearing. Despite prior systematic reviews and meta-analyses on the role of RRSO in reducing the mortality and incidence of breast, HGSC and other cancers, RRSO is still an area of debate and it is unclear whether RRSO differs in effectiveness by type of mutation carried.

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Objective To assess the association of RRSO with the risk of breast cancer in women with BRCA1 and BRCA2 pathogenic variants. The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly for BRCA2 mutation carriers. Risk-reducing salpingo-oophorectomy (RRSO) has been widely adopted as a key component of breast and gynecologic cancer risk-reduction for women with BRCA1 and BRCA2 mutations.

doi: 10.1001/jamaoncol.2020.7995. Online ahead of print. The salpingo-oophorectomy group included all women who had a risk-reducing salpingo-oophorectomy with or without concomitant hysterectomy after the receipt of genetic-test results. Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is recommended between age 35 and 40 and between age 40 and 45 years for women carriers of BRCA1 and BRCA2 mutations, respectively. Consequently, most BRCA mutation carriers undergo this procedure prior to a natural menopause and develop an anticipated lack of hormones. Sometimes healthy ovaries and fallopian tubes are removed to help prevent ovarian cancer in women who are at particularly high risk. This is known as a risk-reducing salpingo-oophorectomy.

Despite prior systematic reviews and meta-analyses on the role of RRSO in reducing the mortality and incidence of breast, HGSC and other cancers, RRSO is still an area of debate and it is unclear whether RRSO differs in effectiveness by type of mutation carried.

Prophylactic bilateral oophorectomy is a surgical procedure that removes both ovaries. The goal of this surgery is to reduce the risk of ovarian, fallopian tube,

Oct 22, 2015 have a significantly higher lifetime risk of ovarian and breast cancers early stage ovarian cancer, risk-reducing salpingo-oophorectomy has Nov 5, 2019 Hence, prophylactic BSO in patients with BRCA1 or BRCA2 mutation has been shown to reduce ovarian cancer risk by 96% [4]. It has also been May 9, 2019 This video shows the surgical technique to perform a step-by-step Risk- Reduction Saplingo-Oophorectomy (RRSO) in BRCA mutation carriers Dec 3, 2014 Prophylactic Oophorectomy for Reducing Ovarian Cancer Risk Markman, MD, discuss the role of prophylactic oophorectomy for BRCA-positive women. The Benefits and Risks of Bilateral Salpingo-Oophorectomy in the . Aug 9, 2016 of America, discusses the benefits and risks of performing a bilateral salpingo- oophorectomy as a treatment for patients with ovarian cancer.

The randomised controlled trial, ‘Psychosexual conseqUences of Risk‐reducing Salpingo‐oophorectomy in BRCA1/2 mUtation carriErs’ (PURSUE) study is an open‐label trial and was approved by the Medical Ethical Committee of the University Medical Center Groningen on 14 November 2014 (registration no. NL46796.042.14).

Risk Assessment, Genetic Counseling, and Genetic Testing for Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants : a Prospective Lynch Risk-reducing salpingo-oophorectomy in patients with germline mutations in BRCA1 or BRCA2.

based on it – to have a bilateral mastectomy and salpingo-oophorectomy. Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.
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Kauff, N.D. et al. (2005). Risk of ovarian cancer Sjukdomsbördan i Sverige och dess riskfaktorer Svensk tillämpning av WHO:s "DALY-metod" för beräkning av sjukdomsbörda och riskfaktorermore.
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The randomised controlled trial, ‘Psychosexual conseqUences of Risk‐reducing Salpingo‐oophorectomy in BRCA1/2 mUtation carriErs’ (PURSUE) study is an open‐label trial and was approved by the Medical Ethical Committee of the University Medical Center Groningen on 14 November 2014 (registration no. NL46796.042.14).

Objective: To assess the association of RRSO with the risk of breast cancer in women with BRCA1 and BRCA2 pathogenic variants. 2020-11-01 · Among 269 patients who underwent risk-reducing bilateral salpingo-oophorectomies, 220 procedures were performed by gynecologic oncologists, and 49 were performed by benign gynecologists. Washings were not performed in 5% of the procedures performed by gynecologic oncologists and 37% of the procedures performed by benign gynecologists (p <.001). Background: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain.